Order Gabapentin 600MG from TopeMeds Online Pharmacy

Gabapentin (as conventional preparations) is used in combination with other anticonvulsant agents in the management of partial seizures with or without secondary generalization. The anticonvulsant potential of gabapentin has been established in studies in which gabapentin or placebo was administered as adjunctive therapy in adults and children 3 years of age or older with refractory partial seizures; comparative efficacy of therapeutically effective dosages of gabapentin versus other anticonvulsants remains to be established.

Neuropathic Pain

Postherpetic Neuralgia

Gabapentin (as conventional preparations or gastroretentive tablets) and gabapentin enacarbil are used in the management of postherpetic neuralgia (PHN) in adults. Gabapentin is considered one of several first-line therapies for the management of neuropathic pain associated with PHN; other options include tricyclic antidepressants, pregabalin, opiate analgesics, and topical lidocaine patches. When selecting an appropriate regimen, clinicians should consider the relative efficacy and safety of the specific drugs as well as individual patient-related factors (e.g., age, preference, tolerance, contraindications, comorbid conditions, concomitant medications).


 

Efficacy of conventional (immediate-release) preparations of gabapentin for the management of PHN was established in 2 placebo-controlled studies of 7-8 weeks' duration in patients who were continuing to experience pain for longer than 3 months after healing of their herpes zoster rash. In these studies, gabapentin was titrated over several weeks up to a target dosage of 1.8, 2.4, or 3.6 g daily (administered in 3 divided doses as conventional preparations). Gabapentin substantially reduced weekly mean pain scores from baseline compared with placebo (assessed by an 11-point numeric rating scale); improvement was noted at 1 week and maintained throughout the duration of these studies. In addition, a greater proportion of patients receiving gabapentin compared with placebo achieved at least a 50% reduction in pain from baseline, and this was observed at all dosages evaluated.

Other Types of Neuropathic Pain

Gabapentin is used for the treatment of pain associated with diabetic neuropathy. In an 8-week controlled clinical study in patients with diabetic neuropathy, gabapentin was more effective than placebo in improving pain (based on an 11-point numeric rating scale), sleep, and mood during weeks 2-8 of the study. Most patients in this study (67%) received gabapentin in dosages of 3.6 g daily. In addition, 2 comparative studies reported that gabapentin was at least as effective as amitriptyline in relieving pain associated with diabetic neuropathy. Analysis of data from randomized studies in patients with pain associated with diabetic neuropathy indicates that 40% of patients who received gabapentin for neuropathic pain obtained good pain relief.

Gabapentin also has been used with some evidence of benefit for the relief of chronic neurogenic pain in a variety of conditions including trigeminal neuralgia, pain and control of paroxysmal symptoms of multiple sclerosis, complex regional pain syndromes (CRPS), HIV-related peripheral neuropathy, and neuropathic pain associated with cancer. Additional study and experience are needed to further elucidate the precise role of gabapentin in the management of these conditions. Limited evidence indicates that gabapentin is not effective for the management of acute pain. Order gabapentin online from TopeMeds.

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